Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription

Abstract Introduction Despite the long-observed correlation between H3K9me3, chromatin architecture, and transcriptional repression, how H3K9me3 regulates genome higher-order organization and transcriptional activity in living cells remains unclear.Result Here, we develop EpiGo (Epigenetic perturbation induced Genome organization)-KRAB to introduce

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The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial.

BackgroundHelminth infections are proposed to have immunomodulatory activities affecting health outcomes either detrimentally or beneficially.We evaluated glitter foam vellen action the effects of albendazole treatment, every three months for 21 months, on STH, malarial parasitemia and allergy.Methods and findingsA household-based cluster-randomize

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